2-(4-Isopropyl-piperazin-1-yl)-5-nitro-pyrimidine → HCID 61146131, compound

HRID 2409630Notes

Reaction equation

HRID 2409630 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][N:11]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]>C(Cl)Cl.CO>[CH:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[N:15]=[CH:14][C:13]([NH2:16])=[CH:12][N:11]=2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 669146672-(4-Isopropyl-piperazin-1-yl)-5-nitro-pyrimidine

Product 1

HCID 61146131HCID 61146131, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 33.1 but using 2-(4-isopropyl-piperazin-1-yl)-5-nitro-pyrimidine (Step 35.2) and stirring the reaction mixture for 1.5 h. The title compound: ESI-MS: 222.1 [M+H]+; TLC: Rf=0.13 (DCM/MeOH/NH3aq, 94:5:1).

Workup

  1. customThe title compound was prepared in analogy to the procedure

Sources & evidence

ORD record
ord-aeaecabff9a04a789908bf0f2b4e01d4
Source dataset
uspto-grants-2014_08
Patent number
US08815901B2

Reaction notes

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