HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorophenylboronic acid → 8-(2-Fluoro-phenyl)-quinoxaline-5-carboxylic acid [4-(2-dimethylamino-ethoxy)phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorophenylboronic acid | HCID 2734354 | — |
| Reactant | 4-[2-(Dimethylamino)ethoxy]aniline | HCID 6484655 | — |
| Reactant | HCID 66914618 | HCID 66914618 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 8-(2-Fluoro-phenyl)-quinoxaline-5-carboxylic acid [4-(2-dimethylamino-ethoxy)phenyl]-amide | HCID 44515353 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Step 14.1 but stirring the reaction mixture overnight and using 4-(2-dimethylamino-ethoxy)-phenylamine (Step 5.1) and 8-(2-fluoro-phenyl)-quinoxaline-5-carboxylic acid. The latter compound was prepared as described in Steps 1.2-1.7 but using 2-fluorophenylboronic acid in Step 1.4. Title compound: ESI-MS: 431.0 [M+H]+; tR=3.93 min (System 1); TLC: Rf=0.29 (DCM/MeOH/NH3aq, 96:3:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815901B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-8df4ab180b7646b8804b72acde0f0f67 |
| Source note | uspto-grants-2014_08 |