HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2409728Generated: October 27, 2026
Sodium Bicarbonate → 8-(2,6-Difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(3-oxo-piperazin-1-ylmethyl)-pyridin-2-yl]-amide
https://huagongshe.com/reaction/2409728
Participants
| Role | Name | HCID | Charge |
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| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Trimethylaluminum | HCID 16682925 | — |
| Reactant | 4-[(6-Aminopyridin-3-yl)methyl]piperazin-2-one | HCID 62183381 | — |
| Reactant | 8-(2,6-Difluoro-3,5-dimethoxyphenyl)quinoxaline-5-carboxylic acid ethyl ester | HCID 86641145 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 8-(2,6-Difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(3-oxo-piperazin-1-ylmethyl)-pyridin-2-yl]-amide | HCID 44513202 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Example 115 but using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 124.1), 4-(6-amino-pyridin-3-ylmethyl)-piperazin-2-one (Step 103.1), 1.5 equiv of trimethyl aluminum, stirring the reaction mixture for 7 h at 80° C. and pouring it onto a saturated aqueous solution of NaHCO3 and DCM. The title compound: ESI-MS: 535.1 [M+H]+; tR=3.50 min (System 1); TLC: Rf=0.16 (DCM/MeOH/NH3aq, 94:5:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08815901B2 |
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| Source dataset | uspto-grants-2014_08 |
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| ORD ID | ord-f104e14c9cdf4b3688e671e95dfdf9c9 |
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| Source note | uspto-grants-2014_08 |
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