HCID 44513536, compound → HCID 59292873, compound

Participants

Reaction Steps

A suspension of 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid (1-benzyl-1H-imidazol-2-yl)-amide (Example 160) (100 mg, 1.16 mmol) and palladium hydroxyde (75 mg) in MeOH (5 mL) was stirred for 72 h at rt, under a hydrogen atmosphere. The reaction mixture was filtered through a pad of celite and concentrated. The residue was purified by silica gel column chromatography (Hex/EtOAc, 1:4) followed by trituration in Et2O to provide 15 mg of the title compound as a yellow solid: ES-MS: 442.9 [M+H]+; tR=4.05 min (System 1); TLC: Rf=0.08 (Hex/EtOAc, 1:4).

Provenance & Evidence