HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-((4-Methylpiperazin-1-yl)methyl)pyridin-2-amine → 5-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-yl]amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-((4-Methylpiperazin-1-yl)methyl)pyridin-2-amine | HCID 59292901 | — |
| Reactant | 5-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid | HCID 59292911 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 5-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-yl]amide | HCID 44514182 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Step 14.1 but using 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid (Step 159.1), 5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine (Example 31; purified by silica gel column chromatography), and stirring the reaction mixture for 20 h at rt. Title compound: ESI-MS: 566.1 [M+H]+; TLC: Rf=0.22 (DCM/MeOH, 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815901B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-21c8e473bf0c46e090a30afc02f36cd4 |
| Source note | uspto-grants-2014_08 |