Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylaluminum | HCID 16682925 | — |
| Reactant | 5-((4-Methylpiperazin-1-yl)methyl)pyridin-2-amine | HCID 59292901 | — |
| Reactant | 5-(2,6-Difluoro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid ethyl ester | HCID 59292908 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 59292928 | HCID 59292928 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Example 115 but using 5-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid ethyl ester (Step 174.1), 5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine (Example 31; purified by silica gel column chromatography), 2 equiv of trimethyl aluminum, stirring the reaction mixture for 2 h at 80° C. Title compound: ESI-MS: 534.1 [M+H]+; tR=3.56 min (System 1); TLC: Rf=0.14 (DCM/MeOH/NH3aq, 94:5:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08815901B2 |
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| Source dataset | uspto-grants-2014_08 |
|---|
| ORD ID | ord-50b375a9d95149678fc712b55e7878cb |
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| Source note | uspto-grants-2014_08 |
|---|
