HCID 67124891, compound → HCID 66587453, compound

HRID 2409817Notes

Reaction equation

HRID 2409817 reaction equation
[N+:1]([C:4]1[N:8]=[CH:7][N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[N:5]=1)([O-])=O>CO.[Pd]>[F:17][C:15]([F:16])([F:18])[C:11]1[CH:10]=[C:9]([N:6]2[CH:7]=[N:8][C:4]([NH2:1])=[N:5]2)[CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 1

HCID 67124891HCID 67124891, compound

Product 1

HCID 66587453HCID 66587453, compoundYield 101.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

Into a 100-mL round bottom flask, was placed a solution of 3-nitro-1-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazole (1 g, 3.88 mmol, 1.00 equiv) in methanol (20 mL). The mixture was treated with Pd/C (1 g) and stirred under an atmosphere of hydrogen for 3 h at 25° C. in an oil bath. The solids were filtered out. The resulting mixture was concentrated under vacuum to yield 900 mg of crude product as a white solid.

Workup

  1. customInto a 100-mL round bottom flask, was placed
  2. filtrationThe solids were filtered out
  3. concentrationThe resulting mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-8be98a54e26f47309dd109bb060cea24
Source dataset
uspto-grants-2014_08
Patent number
US08815910B2

Reaction notes

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