3-(3-(2-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-ylcarbamoyl)-4-(piperidin-1-yl)phenylcarbamoyl)-benzylthio)propanoic acid → 3-((3-((4-(Piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

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Reaction Steps

This compound was prepared from 5-chloro-2-nitro-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide 6c using the procedure described for the preparation of 3-(3-(2-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-ylcarbamoyl)-4-(piperidin-1-yl)phenylcarbamoyl)-benzylthio)propanoic acid 5 from 5-chloro-N-(1-(3,4-dimethylphenyl)-1H-pyrazol-3-yl)-2-nitrobenzamide 4g. 1H-NMR (300 MHz, CD3OD, ppm): δ 8.715 (d, J=6.9 Hz, 1H), 8.390-8.397 (m, 1H), 8.180 (s, 1H), 8.057-8.077 (m, 1H), 8.020 (s, 2H), 7.894-7.914 (m, 1H), 7.679-7.719 (m, 2H), 7.591-7.642 (m, 2H), 7.520-7.558 (m, 1H), 7.147-7.154 (m, 1H), 3.889 (s, 2H), 3.614-3.640 (m, 4H), 2.690-2.725 (m, 2H), 2.563-2.598 (m, 2H), 2.002-2.055 (m, 4H), 1.804-1.818 (m, 2H). MS (ES, m/z): 652 [M+H]+.

Provenance & Evidence