HCID 86690349, compound → HCID 71226842, compound

Participants

Reaction Steps

To a solution of (S)-benzyl (3-methyl-1-(4-(trifluoromethyl)phenyl)piperidin-3-yl)carbamate (2.05 g, 5.22 mmol) in MeOH (20 mL) was added palladium on carbon (0.406 g, 3.81 mmol) under nitrogen atmosphere. The resultant black color suspension was stirred under hydrogen balloon pressure at rt for 2 hours. The reaction mass was filtered on Celite, the filter cake was washed with methanol (3×10 mL), and combined filtrate was concentrated and dried under vacuum to get 1.6 g of crude compound. This crude was purified on a 12 g silica cartridge by ISCO, eluted the compound around 5% methanol in chloroform. Pure fractions were collected and concentrated to get (S)-3-methyl-1-(4-(trifluoromethyl)phenyl)piperidin-3-amine (570 mg, 1.493 mmol, 28.6% yield) as pale yellow gummy solid.

Provenance & Evidence