HCID 71233209, compound → HCID 71233212, compound

Participants

Reaction Steps

To a solution of benzyl ((1R,2R)-2-(((S)-3-methyl-1-(4-(trifluoromethyl)phenyl)piperidin-3-yl)amino)cyclohexyl)carbamate (420 mg, 0.858 mmol) in MeOH (4 mL) was added palladium on carbon (10%) (84 mg, 0.789 mmol) under nitrogen atmosphere. The resultant black color suspension was stirred under hydrogen balloon pressure at RT for 2 h. The reaction mass was filtered on Celite and the filter cake was washed with methanol (3×5 mL). The filtrate was concentrated and dried under vacuum to get (1R,2R)—N1-((S)-3-methyl-1-(4-(trifluoromethyl)phenyl)piperidin-3-yl)cyclohexane-1,2-diamine (300 mg, 0.667 mmol, 78% yield) as off white solid. This was directly used for next reaction with out any further purification. Anal. Calcd. for C19H28F3N3 m/z 355.4, found: 490.4 (M+H)+; This was taken for next step with out any further characterization.

Provenance & Evidence