Trifluoroacetic acid → HCID 71227046, compound

Participants

Reaction Steps

To a round bottom flask was aded (Z)-tert-butyl 3-(2-(((1R,2R)-2-(((S)-1-(4-cyanophenyl)piperidin-3-yl)amino)cyclohexyl)amino)pyridin-4-yl)acrylate (30 mg, 0.060 mmol), TFA (1 mL) and CH2Cl2 (1 mL). The reaction was stirred at rt overnight. The reaction was concentrated and dried to give (Z)-3-(2-(((1R,2R)-2-(((S)-1-(4-cyanophenyl)piperidin-3-yl)amino)cyclohexyl)amino)pyridin-4-yl)acrylic acid (29 mg, 0.049 mmol, 82% yield) as a beige solid. Anal. Calcd. for C26H31N5O2 m/z 445.5, found: 446.4 (M+H)+.

Provenance & Evidence