HCID 86703272, compound → HCID 86703273, compound

Participants

Reaction Steps

To a solution of benzyl 6-(1-benzenesulfonyl-6-methoxy-2-phenyl-1H-indol-3-ylmethyl)pyridine-2-carboxylate (1.10 g) in ethyl acetate (9.3 mL) was added 10% palladium on carbon (56.5% water included, 253 mg), and this mixture was stirred at room temperature for 100 minutes under a hydrogen atmosphere. The reaction mixture was filtrated through a Celite (registered trademark) pad. The filtrate was concentrated under reduced pressure to obtain the title compound (869 mg). 1H-NMR (DMSO-d6) δ ppm: 3.84 (3H, s), 3.97 (2H, s), 6.87 (1H, dd, J=2.3, 8.6 Hz), 6.95-7.02 (1H, m), 7.30 (1H, d, J=8.6 Hz), 7.40-7.51 (7H, m), 7.56-7.68 (4H, m), 7.70-7.85 (2H, m), 12.80-13.60 (1H, br).

Provenance & Evidence