Ammonia → HCID 68184812, compound

Participants

Reaction Steps

Benzyl 6-(6-cyclopropyl-2-phenyl-1H-indol-3-ylmethyl)pyridine-2-carboxylate (200 mg) was dissolved in a solution of ammonia in methanol (about 7 mol/L, 3.3 mL). This solution was stirred at room temperature for 17 hours. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluting solvent: ethyl acetate-hexane) to obtain the title compound (138 mg). 1H-NMR (CDCl3) δ ppm: 0.69-0.77 (2H, m), 0.92-1.02 (2H, m), 1.97-2.06 (1H, m), 4.42 (2H, s), 5.38-5.59 (1H, br), 6.86 (1H, dd, J=1.4, 8.2 Hz), 7.11-7.15 (1H, m), 7.24-7.29 (1H, m), 7.32-7.48 (4H, m), 7.51-7.58 (2H, m), 7.63-7.71 (1H, m), 7.76-7.96 (1H, br), 7.97-8.03 (1H, m), 8.08 (1H, br).

Provenance & Evidence