Hydrochloric Acid → HCID 86703290, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-(1-benzenesulfonyl-6-methoxy-2-phenyl-1H-indol-3-ylmethyl)-N-methanesulfonylpyridine-2-carboxamide (632 mg) in tetrahydrofuran/methanol (7.4 mL/3.7 mL) was added cesium carbonate (1.43 g), and this mixture was stirred at 50° C. for 29 hours. Cesium carbonate (1.43 g) was added thereto, and further stirred for additional 45.5 hours. The reaction mixture was left to be cooled. To the reaction mixture was added 1 mol/L hydrochloric acid (20 mL), followed by extraction with ethyl acetate. The organic layer was washed with water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluting solvent: methanol-dichloromethane) to obtain the title compound (375 mg).

Provenance & Evidence