Trifluoroacetic acid → HCID 86703299, compound

Participants

Reaction Steps

To a solution of tert-butyl 6-methoxy-3-(6-methoxycarbonylethynylpyridin-2-ylmethyl)-2-phenylindole-1-carboxylate (100 mg) in dichloromethane (1 mL) was added trifluoroacetic acid (0.3 mL), and the mixture was stirred at room temperature for 3 hours. To the reaction mixture were added dichloromethane and an aqueous sodium hydrogen carbonate solution, and the organic layer was separated and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluting solvent: ethyl acetate-hexane) to obtain the title compound (75.1 mg). 1H-NMR (CDCl3) δ ppm: 3.84-3.89 (6H, m), 4.45 (2H, s), 6.75 (1H, dd, J=2.3, 8.8 Hz), 6.92 (1H, d, J=2.3 Hz), 7.04-7.10 (1H, m), 7.31-7.55 (7H, m), 8.09 (1H, br s). ESI-MS (m/z): 397 (M+H)+

Provenance & Evidence