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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 241008Generated: October 25, 2026

Pyridine-2-carboximidamide hydrochloride → 4-Chloro-6,6-dimethyl-2-(pyridin-2-yl)-5,6,7,8-tetrahydroquinazoline

https://huagongshe.com/reaction/241008

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyridine-2-carboximidamide hydrochlorideHCID 12403615—
ReactantHCID 178425726HCID 178425726—
Product4-Chloro-6,6-dimethyl-2-(pyridin-2-yl)-5,6,7,8-tetrahydroquinazolineHCID 86647814—

Reaction Steps

Synthesized according to the method of reagent preparation 8 by using 2-hydroxy-5,5-dimethylcyclohex-1-enecarboxylate and picolinimidamide hydrochloride in step 2. MS (ES) for C15H16ClN3: 274 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08648066B2
Source datasetuspto-grants-2014_02
ORD IDord-846fb0e8081144d38d3731b4a9a27fae
Source noteuspto-grants-2014_02