2-Amino-4-chloropyridine → HCID 86707758, compound

HRID 2410101Notes

Reaction equation

HRID 2410101 reaction equation
C(O[C:4]([C:6]1[N:7]=[C:8]([Br:24])[N:9]([CH:21]([CH3:23])[CH3:22])[C:10]=1[CH:11]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[CH3:20])O)=[O:5])C.[NH2:25][C:26]1[CH:31]=[C:30]([Cl:32])[CH:29]=[CH:28][N:27]=1>>[Br:24][C:8]1[N:9]([CH:21]([CH3:22])[CH3:23])[C:10]2[CH:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[CH3:20])[N:25]([C:26]3[CH:31]=[C:30]([Cl:32])[CH:29]=[CH:28][N:27]=3)[C:4](=[O:5])[C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 5818662-Amino-4-chloropyridineHCID 86707752HCID 86707752, compound2×

Product 1

HCID 86707758HCID 86707758, compound

Procedure

The title compound was prepared in analogy to the procedure described for step E2 using 2-bromo-5-[(4-chloro-2-methyl-phenyl)-hydroxy-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester (intermediate C) and 2-amino-4-chloro-pyridine as starting materials. tR: 1.42 min (LC-MS 1); ESI-MS: 527.2 [M+H]+ (LC-MS 1).

Sources & evidence

ORD record
ord-f184823f5d2246d4bd4a024d967d2162
Source dataset
uspto-grants-2014_08
Patent number
US08815926B2

Reaction notes

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