Morpholine → HCID 89719988, compound

HRID 2410102Notes

Reaction equation

[C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:13][CH3:14])=[C:8]([B:10]([OH:12])[OH:11])[CH:9]=1)([OH:3])=O.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[N:15]1([C:1]([C:4]2[CH:5]=[CH:6][C:7]([O:13][CH3:14])=[C:8]([B:10]([OH:12])[OH:11])[CH:9]=2)=[O:3])[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 426145415-Carboxy-2-methoxybenzeneboronic acid

Product 1

HCID 89719988HCID 89719988, compound

Procedure

The title compound was prepared in analogy to the procedure described for intermediate K using 5-carboxy-2-methoxyphenyl boronic acid and morpholine; ESI-MS: 266.5 [M+H]+ (LC-MS 2); 1H-NMR (DMSO-d6, 400 MHz) δ 7.84 (s, 1H), 7.57 (d, 1H), 7.46 (d, 1H), 7.03 (d, 1H), 3.83 (s, 3H), 3.62-3.60 (m, 4H), 3.49-3.42 (m, 4H).

Sources & evidence

ORD record: ord-38ee0cdcb6cf4ef987e4aef4db9d845e
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08815926B2

Reaction notes

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