Acetyl chloride → HCID 86707771, compound

Participants

Reaction Steps

The product from example 16 (30 mg, 0.05 mmol) was dissolved in THF (0.7 mL) and TEA (10 mL, 0.07 mmol) was added. The reaction was cooled in an ice bath and acetyl chloride (5 mL, 0.06 mmol) was added. The cooling bath was removed and the reaction mixture allowed to stir at rt for 0.5 h. It was then diluted with EtOAc and brine and the aqueous phase extracted with EtOAc. The combined extracts were dried (Na2SO4) and concentrated. The remaining crude product was triturated with acetonitrile to give the title compound as a white solid, which was isolated by filtration and dried under reduced pressure. tR: 1.18/1.21 min (LC-MS 2); ESI-MS: 591.2/593.2 [M+H]+ (LC-MS 2).

Provenance & Evidence