Acetonitrile → HCID 86703140, compound

Participants

Reaction Steps

A solution of 4-bromo-2-chloro-5-methoxypyridine (1 g, 4.5 mmol) in dimethyl sulfate (1.9 mL, 19.5 mmol) was stirred at 120° C. for 16 h in a sealed tube. After cooling, acetonitrile and a saturated aqueous NaHCO3 solution were added and the mixture was stirred at rt over week-end. DCM was added and extracted. The organic layer was dried (Na2SO4), filtered and concentrated to give the title compound. tR: 0.57 min (LC-MS 2); ESI-MS: 218.0/220.0 [M+H]+ (LC-MS 2).

Provenance & Evidence