HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Methylcyclohexane-1-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | HCID 178461286 | HCID 178461286 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Methylcyclohexane-1-carbonyl chloride | HCID 12986357 | — |
Reaction Steps
To a solution of trans-4-methyl-1-cyclohexane carboxylic acid (8.2 g, 56.5 mmol) in CH2Cl2 (350 mL) at 0° C. was added DMF (44 μl, 0.6 mmol) and oxalyl chloride (11.5 g, 90.0 mmol) dropwise. The reaction mixture was stirred at rt for 18 h. The reaction mixture was concentrated. The product was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815926B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-014dfda2ce8b4f6ab6eaccf7b0e9c47a |
| Source note | uspto-grants-2014_08 |