Hydrochloric Acid → HCID 86707776, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-(4-chloro-5-methoxypyridin-2-yl)acetonitrile (150 mg, 0.8 mmol) in EtOH (2 mL) was added a solution of KOH (184 mg, 3.3 mmol) in H2O (2 mL) and the mixture was stirred at 80° C. for 1.5 h. at 0° C., the pH was adjusted to 3-4 with HCl 1 M. Sodium chloride, THF and EtOAc were added and the phases were separated. The organic layer was dried (MgSO4), filtered and concentrated to afford the title compound. tR: 0.59 min (LC-MS 2); ESI-MS: 202.1 [M+H]+ (LC-MS 2).

Provenance & Evidence