Methylamine hydrochloride → HCID 86707777, compound

HRID 2410131Notes

Reaction equation

HRID 2410131 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:40])=[C:6]([N:8]2[C:15](=[O:16])[C:14]3[N:13]=[C:12]([C:17]4[CH:18]=[C:19]([CH2:25][C:26]([OH:28])=O)[CH:20]=[N:21][C:22]=4[O:23][CH3:24])[N:11]([CH:29]([CH3:31])[CH3:30])[C:10]=3[CH:9]2[C:32]2[CH:37]=[CH:36][C:35]([C:38]#[N:39])=[CH:34][CH:33]=2)[CH:7]=1.Cl.[CH3:42][NH2:43]>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:40])=[C:6]([N:8]2[C:15](=[O:16])[C:14]3[N:13]=[C:12]([C:17]4[CH:18]=[C:19]([CH2:25][C:26]([NH:43][CH3:42])=[O:28])[CH:20]=[N:21][C:22]=4[O:23][CH3:24])[N:11]([CH:29]([CH3:31])[CH3:30])[C:10]=3[CH:9]2[C:32]2[CH:33]=[CH:34][C:35]([C:38]#[N:39])=[CH:36][CH:37]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 6364545Methylamine hydrochlorideHCID 86707778HCID 86707778, compound

Product 1

HCID 86707777HCID 86707777, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described for example 147 but using the product from example 146 and methylamine hydrochloride. tR: 0.97 min (LC-MS 2); ESI-MS: 569.3/571.3 [M+H]+ (LC-MS 2); Rf=0.15 (CH2Cl2/MeOH, 20:1).

Sources & evidence

ORD record
ord-1f94caa40210456989005f95fb95882d
Source dataset
uspto-grants-2014_08
Patent number
US08815926B2

Reaction notes

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