Methanol → Methyl 2-(3-bromo-4-methoxyphenyl)acetate

Participants

Reaction Steps

A solution of 3-bromo-4-methoxyphenylacetic acid (7.5 g, 30.6 mmol), MeOH (24 mL) and H2SO4 (0.8 mL) was stirred at 75° C. for 17 h. The reaction mixture was concentrated. The residue was poured into H2O and extracted with CH2Cl2. The organic layer was washed with brine, dried (NaSO4), filtered and concentrated to afford the title compound. tR: 0.99 min (LC-MS 2).

Provenance & Evidence