HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloropyridine-2-carboxaldehyde → HCID 86707784, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloropyridine-2-carboxaldehyde | HCID 10103267 | — |
| Reactant | ethyl 2-bromo-5-((4-chlorophenyl)(hydroxy)methyl)-1-isopropyl-1H-imidazole-4-carboxylate | HCID 86707749 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86707784 | HCID 86707784 | — |
Reaction Steps
The title compound was obtained in analogy to the procedure described for intermediate B but using 5-chloro-2-formylpyridine. After completion, the reaction mixture was diluted with EtOAc and extracted with a saturated NaHCO3 solution. The organic layer was dried (Na2SO4), filtered and concentrated. The residue was purified by flas chromatography (heptane/EtOAc, 100:0→0:100) to give the title compound. tR: 1.00 min (LC-MS 2); ESI-MS: 402.0/404.0 [M+H]+ (LC-MS 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815926B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-881f02d5606a44de8bcc21c6abf88747 |
| Source note | uspto-grants-2014_08 |