反应详情

A suspension of 2,3-diamino-5-bromopyridine (3.0 g, 16.00 mmol) in formic acid (30 mL) was heated to reflux for 3 hours. After cooling the reaction mixture to room temperature it was concentrated and the residue was taken into 50% ethyl acetate in toluene (100 mL) then concentrated and the process repeated once more to remove excess formic acid. The resulting solid was triturated with ethyl acetate and the solid residue collected by filtration to give 6-bromo-1H-imidazo[4,5-b]pyridine (3.7 g, 95%). GCMS (EI) for C6H4BrN3: 198 (M+).

1. temperaturewas heated
2. temperatureto reflux for 3 hours
3. concentrationwas concentrated
4. concentrationthen concentrated
5. customto remove excess formic acid
6. customThe resulting solid was triturated with ethyl acetate
7. filtrationthe solid residue collected by filtration