Oxane-4-carboxylic acid → HCID 66745852, compound

HRID 2410173Notes

Reaction equation

HRID 2410173 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH2:13][C:14]([NH2:17])([CH3:16])[CH3:15])[N:5]=[C:4]([CH3:18])[C:3]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20].[O:24]1[CH2:29][CH2:28][CH:27]([C:30](O)=[O:31])[CH2:26][CH2:25]1>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH2:13][C:14]([CH3:16])([NH:17][C:30]([CH:27]2[CH2:28][CH2:29][O:24][CH2:25][CH2:26]2)=[O:31])[CH3:15])[N:5]=[C:4]([CH3:18])[C:3]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20]

Participants

3

Reactant 2

HCID 219302Oxane-4-carboxylic acidHCID 66746535HCID 66746535, compound

Product 1

HCID 66745852HCID 66745852, compound

Procedure

Prepared as in Example Da from ethyl 4-amino-5-(2-amino-2-methylpropoxy)-2-methylquinoline-3-carboxylate (Example Db) and tetrahydro-2H-pyran-4-carboxylic acid as a pale-yellow solid (63%). MS 430 (MH+).

Sources & evidence

ORD record
ord-51f68e1bc55941088e4b7fd7465865b4
Source dataset
uspto-grants-2014_08
Patent number
US08815956B2

Reaction notes

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