2-Amino-6-fluorobenzonitrile → HCID 66746574, compound

HRID 2410191Notes

Reaction equation

HRID 2410191 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9](=[O:12])[CH2:10][CH3:11])[CH2:5][CH2:4]1.[NH2:13][C:14]1[CH:21]=[CH:20][CH:19]=[C:18](F)[C:15]=1[C:16]#[N:17]>>[NH2:13][C:14]1[CH:21]=[CH:20][CH:19]=[C:18]([O:1][CH2:2][CH:3]2[CH2:4][CH2:5][N:6]([C:9](=[O:12])[CH2:10][CH3:11])[CH2:7][CH2:8]2)[C:15]=1[C:16]#[N:17]

Participants

3

Reactant 2

HCID 5226592-Amino-6-fluorobenzonitrileHCID 28345355HCID 28345355, compound

Product 1

HCID 66746574HCID 66746574, compound

Procedure

Prepared as in Example 22a from 1-(4-(hydroxymethyl)piperidin-1-yl)propan-1-one (Example 21c) and 2-amino-6-fluorobenzonitrile as a pale-yellow solid (15%). MS 288 (MH+).

Sources & evidence

ORD record
ord-54f85e5ee47e4244b8d148107b35df8c
Source dataset
uspto-grants-2014_08
Patent number
US08815956B2

Reaction notes

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