HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 5-Bromo-2,4-dimethoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 5-Bromo-2,4-dihydroxybenzoic acid | HCID 81814 | — |
| Product | 5-Bromo-2,4-dimethoxybenzoic acid | HCID 13505097 | — |
Reaction Steps
1.1 A solution of 15 g of 5-bromo-2,4-dihydroxybenzoic acid, 14.4 ml of iodomethane and 62.9 g of caesium carbonate in 100 ml of N,N-dimethylformamide (DMF) is heated under reflux for 16 hours. The mixture is subjected to conventional work-up, giving 16.7 g of 5-bromo-2,4-dimethoxybenzoic acid (“1”).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816070B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-e72a2cfced644ffcabb47167e511f227 |
| Source note | uspto-grants-2014_08 |