1-Bromo-2-methylpropane → HCID 69321934, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-hydroxy-2,2-dimethyl-4H-1,3-benzodioxin-4-one (880 mg, 4.53 mmol), potassium carbonate (1.89 g, 13.7 mmol) and isobutyl iodide (0.52 mL, 4.6 mmol) in N,N-dimethylformamide (5 mL) in a sealed tube was stirred at 80° C. After being stirred for 8 h, additional reagents (potassium carbonate: 2.0 g, 14 mmol; isobutyl bromide: 1.0 mL, 9.2 mmol) were added to the mixture, and the mixture was stirred at 130° C. for 10 h. After cooling to 80° C., methanol (3 mL) was added to the mixture, and the mixture was stirred further 15 h. Then the mixture was cooled to room temperature, diluted with ethyl acetate and washed with brine. The organic layer was dried over magnesium sulfate and concentrated in vacuo to give 836 mg (82%) of the title compound as a solid.

Provenance & Evidence