1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine → HCID 69321859, compound

HRID 2410333Notes

Reaction equation

HRID 2410333 reaction equation
[CH2:1]([O:5][C:6]1[C:11]2[C:12]([OH:15])=[N:13][O:14][C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH:2]([CH3:4])[CH3:3].O[CH2:17][CH:18]1[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]1.OCCC1CCN(C(OC(C)(C)C)=O)CC1>>[CH2:1]([O:5][C:6]1[C:11]2[C:12]([O:15][CH2:17][CH:18]3[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:28])([CH3:30])[CH3:29])=[O:25])[CH2:20][CH2:19]3)=[N:13][O:14][C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH:2]([CH3:4])[CH3:3]

Participants

4

Reactant 3

HCID 8541401-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidineHCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylateHCID 178450111HCID 178450111, compound

Product 1

HCID 69321859HCID 69321859, compound

Procedure

The title compound was prepared according to the procedure described in Step 2 of EXAMPLE 7 using 4-isobutoxy-1,2-benzisoxazol-3-ol (EXAMPLE 8, Step 2) and tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate instead of 4-(benzyloxy)-1,2-benzisoxazol-3-ol and tert-butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate.

Sources & evidence

ORD record
ord-3c7f0bfe650048bf8be0c8c93e935b9d
Source dataset
uspto-grants-2014_08
Patent number
US08816090B2

Reaction notes

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