Chlorosuccinimide → HCID 86622732, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-fluoro-6-isobutoxybenzaldehyde oxime (0.99 g, 6.1 mmol, EXAMPLE 16, Step 3) in N,N-dimethylformamide (20 mL) was added N-chlorosuccinimide (0.63 g, 4.7 mmol) at 0° C. The mixture was heated at 50° C. for 1 h and cooled to room temperature. The mixture was diluted with ethylacetate (30 mL) and hexane (30 mL). The organic layer was washed with water (30 mL×2), dried over magnesium sulfate and concentrated in vacuo to give an oil. The residual oil was purified by silica gel column chromatography (hexane/ethyl acetate 9:1 to 4:1) to give 1.04 g (90%) of the title compound as a pale yellow oil.

Provenance & Evidence