1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine → HCID 69319805, compound

HRID 2410347Notes

Reaction equation

HRID 2410347 reaction equation
[CH2:1]([O:8][C:9]1[C:14]2[C:15]([OH:18])=[N:16][O:17][C:13]=2[CH:12]=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O[CH2:20][CH:21]1[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]1.OCCC1CCN(C(OC(C)(C)C)=O)CC1>>[CH2:1]([O:8][C:9]1[C:14]2[C:15]([O:18][CH2:20][CH:21]3[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:31])([CH3:33])[CH3:32])=[O:28])[CH2:23][CH2:22]3)=[N:16][O:17][C:13]=2[CH:12]=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 8541401-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidineHCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylateHCID 178518986HCID 178518986, compound

Product 1

HCID 69319805HCID 69319805, compound

Procedure

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 8 using 4-(benzyloxy)-1,2-benzisoxazol-3-ol (EXAMPLE 7, Step 1) and tert-butyl 4-(hydroxymethyl)-piperidine-1-carboxylate instead of 4-(benzyloxy)-1,2-benzisoxazol-3-ol and tert-butyl 4-(2-hydroxyethyl)-piperidine-1-carboxylate.

Sources & evidence

ORD record
ord-0b1a140b1e9e4ca0a9258a686c08078e
Source dataset
uspto-grants-2014_08
Patent number
US08816090B2

Reaction notes

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