HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Bromomethyl)cyclobutane → tert-Butyl 4-({[4-(cyclobutylmethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Bromomethyl)cyclobutane | HCID 2734658 | — |
| Reactant | Methyl 4-{[4-(2-{[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}ethyl)piperidin-1-yl]methyl}-tetrahydro-2H-pyran-4-carboxylate | HCID 69317424 | — |
| Reactant | HCID 136263840 | HCID 136263840 | — |
| Product | tert-Butyl 4-({[4-(cyclobutylmethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidine-1-carboxylate | HCID 69317583 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Step 7 of EXAMPLE 7 using tert-butyl 4-{[(4-hydroxy-1,2-benzisoxazol-3-yl)oxy]methyl}piperidine-1-carboxylate (EXAMPLE 17, Step 2) and (bromomethyl)cyclobutane instead of methyl 4-[(4-{2-[(4-hydroxy-1,2-benzisoxazol-3-yl)oxy]ethyl}piperidin-1-yl)methyl]tetrahydro-2H-pyran-4-carboxylate and 2,2,2-trifluoroethyl trifluoromethanesulfonate (Step 7 of EXAMPLE 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816090B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-e84bbf06dfac433286907b5699fca61c |
| Source note | uspto-grants-2014_08 |