Methyl 2,2-dimethyl-3-oxopropanoate → Methyl 3-[4-({[4-(cyclobutylmethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]-2,2-dimethylpropanoate

Participants

Role	Name	HCID	Charge
Reactant	Methyl 2,2-dimethyl-3-oxopropanoate	HCID 11137194	—
Reactant	Methyl 1-formylcyclobutane-1-carboxylate	HCID 15656335	—
Reactant	4-(Cyclobutylmethoxy)-3-(Piperidin-4-ylmethoxy)-1,2-benzisoxazole	HCID 69319723	—
Product	Methyl 3-[4-({[4-(cyclobutylmethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]-2,2-dimethylpropanoate	HCID 69318763	—

Reaction Steps

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 2 using 4-(cyclobutylmethoxy)-3-(piperidin-4-ylmethoxy)-1,2-benzisoxazole (EXAMPLE 17, Step 4) and methyl 2,2-dimethyl-3-oxopropanoate (Tetrahedron Asymmetry 2003, 14, 3371-3378) instead of 3-(piperidin-4-ylmethoxy)-4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazole and methyl 1-formylcyclobutan-carboxylate.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08816090B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-f46770403b734d4aa341d89e3d66c817
Source note	uspto-grants-2014_08