HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentane-1,3-diol → tert-Butyl 4-[({4-[(trans-3-hydroxycyclopentyl)oxy]-1,2-benzisoxazol-3-yl}oxy)methyl]piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentane-1,3-diol | HCID 100165 | — |
| Reactant | 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine | HCID 854140 | — |
| Reactant | HCID 136263840 | HCID 136263840 | — |
| Product | tert-Butyl 4-[({4-[(trans-3-hydroxycyclopentyl)oxy]-1,2-benzisoxazol-3-yl}oxy)methyl]piperidine-1-carboxylate | HCID 69319191 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Step 2 of EXAMPLE 7 using tert-butyl 4-{[(4-hydroxy-1,2-benzisoxazol-3-yl)oxy]methyl}piperidine-1-carboxylate (EXAMPLE 17, step 2) and 1,3-cyclopentanediol (mixture of isomers, cis:trans=ca. 5:1) instead of 4-(benzyloxy)-1,2-benzisoxazol-3-ol and tert-butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816090B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-93640cba850f4f83aeb956d261035a8e |
| Source note | uspto-grants-2014_08 |