Cyclohexene oxide → tert-Butyl 4-[({4-[(trans-2-hydroxycyclohexyl)oxy]-1,2-benzisoxazole-3-yl}oxy)methyl]piperidine-1-carboxylate

HRID 2410372Notes

Reaction equation

[OH:1][C:2]1[C:7]2[C:8]([O:11][CH2:12][CH:13]3[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:14]3)=[N:9][O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH:26]12[O:32][CH:27]1[CH2:28][CH2:29][CH2:30][CH2:31]2>>[OH:32][C@@H:27]1[CH2:28][CH2:29][CH2:30][CH2:31][C@H:26]1[O:1][C:2]1[C:7]2[C:8]([O:11][CH2:12][CH:13]3[CH2:14][CH2:15][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:17][CH2:18]3)=[N:9][O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 9246Cyclohexene oxide

HCID 136263840HCID 136263840, compound

Product 1

HCID 69322323tert-Butyl 4-[({4-[(trans-2-hydroxycyclohexyl)oxy]-1,2-benzisoxazole-3-yl}oxy)methyl]piperidine-1-carboxylate

Procedure

The title compound was prepared according to the procedure described in Step 1 of EXAMPLE 31 using tert-butyl 4-{[(4-hydroxy-1,2-benzisoxazol-3-yl)oxy]methyl}piperidine-1-carboxylate (EXAMPLE 17, step 2) and cyclohexene oxide instead of 1-oxaspiro[2.4]heptane.

Sources & evidence

ORD record: ord-70b8611750864b3f8bafab787258cab2
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816090B2

Reaction notes

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