Methyl 1-formylcyclobutane-1-carboxylate → HCID 178498713, compound

HRID 2410380Notes

Reaction equation

HRID 2410380 reaction equation
[C:1]([O:4][CH2:5][C@H:6]1[CH2:11][CH2:10][C@@H:9]([O:12][C:13]2[C:18]3[C:19]([O:22][CH2:23][CH:24]4[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]4)=[N:20][O:21][C:17]=3[CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:7]1)(=[O:3])[CH3:2].[CH:30]([C:32]1([C:38]([O:40][CH3:41])=[O:39])[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1)=O.C(C1(C(OC)=O)CCC1)=O>>[C:1]([O:4][CH2:5][C@@H:6]1[CH2:7][CH2:8][C@H:9]([O:12][C:13]2[C:18]3[C:19]([O:22][CH2:23][CH:24]4[CH2:25][CH2:26][N:27]([CH2:30][C:32]5([C:38]([O:40][CH3:41])=[O:39])[CH2:37][CH2:36][O:35][CH2:34][CH2:33]5)[CH2:28][CH2:29]4)=[N:20][O:21][C:17]=3[CH:16]=[CH:15][CH:14]=2)[CH2:10][CH2:11]1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 15656335Methyl 1-formylcyclobutane-1-carboxylateHCID 53418117Methyl 4-formyloxane-4-carboxylateHCID 178476337HCID 178476337, compound

Product 1

HCID 178498713HCID 178498713, compound

Procedure

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 2 using (cis-4-{[3-(piperidin-4-ylmethoxy)-1,2-benzisoxazol-4-yl]oxy}cyclohexyl)methyl acetate (EXAMPLE 46, Step 3) and methyl 4-formyltetrahydro-2H-pyran-4-carboxylate (EXAMPLE 18, Step 1) instead of 3-(piperidin-4-ylmethoxy)-4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazole and methyl 1-formylcyclobutanecarboxylate.

Sources & evidence

ORD record
ord-d339164a2c28409d8ad74a0d3f09c581
Source dataset
uspto-grants-2014_08
Patent number
US08816090B2

Reaction notes

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