Cyclobutane-1,1-diyldimethanol → tert-Butyl 4-{[(4-{[1-(hydroxymethyl)cyclobutyl]methoxy}-1,2-benzisoxazol-3-yl)oxy]methyl}-piperidine-1-carboxylate

HRID 2410383Notes

Reaction equation

HRID 2410383 reaction equation
[OH:1][C:2]1[C:7]2[C:8]([O:11][CH2:12][CH:13]3[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:14]3)=[N:9][O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:26]1([CH2:32]O)([CH2:30][OH:31])[CH2:29][CH2:28][CH2:27]1.OCC1CCN(CC2(C(OC)=O)CCCC2)CC1>>[OH:31][CH2:30][C:26]1([CH2:32][O:1][C:2]2[C:7]3[C:8]([O:11][CH2:12][CH:13]4[CH2:14][CH2:15][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:17][CH2:18]4)=[N:9][O:10][C:6]=3[CH:5]=[CH:4][CH:3]=2)[CH2:29][CH2:28][CH2:27]1

Participants

4

Reactant 3

HCID 4498243Cyclobutane-1,1-diyldimethanolHCID 69317059Methyl 1-{[4-(hydroxymethyl)piperidin-1-yl]methyl}cyclopentanecarboxylateHCID 136263840HCID 136263840, compound

Product 1

HCID 69319907tert-Butyl 4-{[(4-{[1-(hydroxymethyl)cyclobutyl]methoxy}-1,2-benzisoxazol-3-yl)oxy]methyl}-piperidine-1-carboxylate

Procedure

The title compound was prepared according to the procedure described in Step 4 of EXAMPLE 9 using tert-butyl 4-{[(4-hydroxy-1,2-benzisoxazol-3-yl)oxy]methyl}piperidine-1-carboxylate (EXAMPLE 17, Step 2) and cyclobutane-1,1-diyldimethanol (DE 19735574) instead of 4-[(4-methoxybenzyl)oxy]-1,2-benzisoxazol-3-ol and methyl 1-{[4-(hydroxymethyl)piperidin-1-yl]methyl}cyclopentanecarboxylate.

Sources & evidence

ORD record
ord-292f589307b24d0584a6979731a6fc67
Source dataset
uspto-grants-2014_08
Patent number
US08816090B2

Reaction notes

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