Methyl 1-formylcyclobutane-1-carboxylate → HCID 69316150, compound

HRID 2410384Notes

Reaction equation

HRID 2410384 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][O:8][C:9]2[C:13]3[C:14]([O:18][CH2:19][C:20]4([CH2:24][OH:25])[CH2:23][CH2:22][CH2:21]4)=[CH:15][CH:16]=[CH:17][C:12]=3[O:11][N:10]=2)[CH2:3][CH2:2]1.[CH:26]([C:28]1([C:34]([O:36][CH3:37])=[O:35])[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1)=O.C(C1(C(OC)=O)CCC1)=O>>[OH:25][CH2:24][C:20]1([CH2:19][O:18][C:14]2[C:13]3[C:9]([O:8][CH2:7][CH:4]4[CH2:5][CH2:6][N:1]([CH2:26][C:28]5([C:34]([O:36][CH3:37])=[O:35])[CH2:33][CH2:32][O:31][CH2:30][CH2:29]5)[CH2:2][CH2:3]4)=[N:10][O:11][C:12]=3[CH:17]=[CH:16][CH:15]=2)[CH2:21][CH2:22][CH2:23]1

Participants

4

Reactant 3

HCID 15656335Methyl 1-formylcyclobutane-1-carboxylateHCID 53418117Methyl 4-formyloxane-4-carboxylateHCID 69319016HCID 69319016, compound

Product 1

HCID 69316150HCID 69316150, compound

Procedure

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 2 using [1-({[3-(piperidin-4-ylmethoxy)-1,2-benzisoxazol-4-yl]oxy}methyl)cyclobutyl]methanol (EXAMPLE 49, Step 2) and methyl 4-formyltetrahydro-2H-pyran-4-carboxylate (EXAMPLE 18, Step 1) instead of 3-(piperidin-4-ylmethoxy)-4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazole and methyl 1-formylcyclobutane-carboxylate.

Sources & evidence

ORD record
ord-60ce7383f1c644b69dedba812f128550
Source dataset
uspto-grants-2014_08
Patent number
US08816090B2

Reaction notes

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