1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine → HCID 69320362, compound

HRID 2410386Notes

Reaction equation

HRID 2410386 reaction equation
[OH:1][C:2]1[C:7]2[C:8]([O:11][CH2:12][CH:13]3[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:14]3)=[N:9][O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.O[CH2:27][C:28]1([C:33]([O:35][CH3:36])=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29]1.OCCC1CCN(C(OC(C)(C)C)=O)CC1>>[CH3:36][O:35][C:33]([C:28]1([CH2:27][O:1][C:2]2[C:7]3[C:8]([O:11][CH2:12][CH:13]4[CH2:14][CH2:15][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:17][CH2:18]4)=[N:9][O:10][C:6]=3[CH:5]=[CH:4][CH:3]=2)[CH2:32][CH2:31][CH2:30][CH2:29]1)=[O:34]

Participants

4

Reactant 3

HCID 8541401-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidineHCID 57686715907608-98-4HCID 136263840HCID 136263840, compound

Product 1

HCID 69320362HCID 69320362, compound

Procedure

The title compound was prepared according to the procedure described in Step 2 of EXAMPLE 7 using tert-butyl 4-{[(4-hydroxy-1,2-benzisoxazol-3-yl)oxy]methyl}piperidine-1-carboxylate (EXAMPLE 17, step 2) and methyl 1-(hydroxymethyl)cyclopentanecarboxylate (EXAMPLE 51, Step 1) instead of 4-(benzyloxy)-1,2-benzisoxazol-3-ol and tert-butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate.

Sources & evidence

ORD record
ord-4e220038dd694f9085ef964d797d96e6
Source dataset
uspto-grants-2014_08
Patent number
US08816090B2

Reaction notes

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