Methyl 1-formylcyclobutane-1-carboxylate → HCID 69319217, compound

HRID 2410388Notes

Reaction equation

HRID 2410388 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][O:8][C:9]2[C:13]3[C:14]([O:18][CH2:19][C:20]4([CH2:25][OH:26])[CH2:24][CH2:23][CH2:22][CH2:21]4)=[CH:15][CH:16]=[CH:17][C:12]=3[O:11][N:10]=2)[CH2:3][CH2:2]1.[CH:27]([C:29]1([C:35]([O:37][CH3:38])=[O:36])[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1)=O.C(C1(C(OC)=O)CCC1)=O>>[OH:26][CH2:25][C:20]1([CH2:19][O:18][C:14]2[C:13]3[C:9]([O:8][CH2:7][CH:4]4[CH2:5][CH2:6][N:1]([CH2:27][C:29]5([C:35]([O:37][CH3:38])=[O:36])[CH2:34][CH2:33][O:32][CH2:31][CH2:30]5)[CH2:2][CH2:3]4)=[N:10][O:11][C:12]=3[CH:17]=[CH:16][CH:15]=2)[CH2:21][CH2:22][CH2:23][CH2:24]1

Participants

4

Reactant 3

HCID 15656335Methyl 1-formylcyclobutane-1-carboxylateHCID 53418117Methyl 4-formyloxane-4-carboxylateHCID 69315747HCID 69315747, compound

Product 1

HCID 69319217HCID 69319217, compound

Procedure

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 2 using [1-({[3-(Piperidin-4-ylmethoxy)-1,2-benzisoxazol-4-yl]oxy}methyl)cyclopentyl]methanol (EXAMPLE 51, Step 4) and methyl 4-formyltetrahydro-2H-pyran-4-carboxylate (EXAMPLE 18, Step 1) instead of 3-(piperidin-4-ylmethoxy)-4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazole and methyl 1-formylcyclobutane-carboxylate.

Sources & evidence

ORD record
ord-6b95be77c83d423c81db199e01ca3b98
Source dataset
uspto-grants-2014_08
Patent number
US08816090B2

Reaction notes

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