3-(Hydroxymethyl)benzonitrile → HCID 86661512, compound

HRID 2410505Notes

Reaction equation

HRID 2410505 reaction equation
NC(=NO)[C:3]1[CH:18]=[CH:17][C:6]([CH2:7][O:8][CH2:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])=[CH:5][CH:4]=1.[C:21](C1C=C(C=CC=1)CO)#[N:22]>>[C:21]([C:18]1[CH:17]=[C:6]([CH:5]=[CH:4][CH:3]=1)[CH2:7][O:8][CH2:9][C:10]([O:12][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:11])#[N:22]

Participants

3

Reactant 2

HCID 27346773-(Hydroxymethyl)benzonitrileHCID 76685345HCID 76685345, compound

Product 1

HCID 86661512HCID 86661512, compound

Procedure

The title compound was prepared following the procedure described for Intermediate 15 Step 1, but starting from 3-cyanobenzyl alcohol. It was obtained as a colorless oil (4.4 g, 78%). HPLC (Method A) Rt 4.55 min (Purity: 98.3%).

Sources & evidence

ORD record
ord-6337221f45d04b5ea1cea5e893519406
Source dataset
uspto-grants-2014_08
Patent number
US08815919B2

Reaction notes

Loading…