2-Methoxyethylamine → HCID 28426087, compound

Participants

Reaction Steps

2-Methoxyethylamine (2.2 mL, 25.5 mmol) was added into a solution of 4-cyanobenzyl bromide (1.0 g, 5.1 mmol) in ACN (10 mL) and the resulting mixture was stirred at RT for 1 hour. The reaction mixture was concentrated under vacuum. The crude product was dissolved in EtOAc, and then washed with a saturated aqueous solution of NaHCO3 and brine, dried (MgSO4) and concentrated under vacuum to give the title compound (958 mg, 99%). LC/MS (Method B): 191.0 (M+H)+. HPLC (Method A) Rt 1.44 min (Purity: 93.4%).

Provenance & Evidence