2-(Methoxymethyl)-2'-methylbiphenyl-4-carboxylic acid → HCID 46940298, compound

HRID 2410576Notes

Reaction equation

HRID 2410576 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]([OH:12])=O)[CH:7]=[CH:6][C:5]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19].[OH:20][CH:21]([CH2:34][OH:35])[CH2:22][NH:23][C:24]1[CH:25]=[C:26]([C:30](=[N:32]O)[NH2:31])[CH:27]=[CH:28][CH:29]=1>>[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]2[O:12][N:32]=[C:30]([C:26]3[CH:25]=[C:24]([NH:23][CH2:22][CH:21]([OH:20])[CH2:34][OH:35])[CH:29]=[CH:28][CH:27]=3)[N:31]=2)[CH:7]=[CH:6][C:5]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19]

Participants

3

Reactant 2

HCID 594958222-(Methoxymethyl)-2'-methylbiphenyl-4-carboxylic acidHCID 86661514HCID 86661514, compound

Product 1

HCID 46940298HCID 46940298, compound

Procedure

The title compound was prepared following the general procedure 4 starting from Intermediate 3 and Intermediate 26. It was purified by preparative HPLC affording the product as a brown powder. LC/MS (Method B): 444.4 (M−H)−, 446.3 (M+H)+. HPLC (Method A) Rt 4.71 min (Purity: 99.4%).

Workup

  1. customIt was purified by preparative HPLC

Sources & evidence

ORD record
ord-f64690b95b7e40cd8d8cd9464852072e
Source dataset
uspto-grants-2014_08
Patent number
US08815919B2

Reaction notes

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