2-(Methoxymethyl)-2'-methylbiphenyl-4-carboxylic acid → HCID 66678210, compound

HRID 2410592Notes

Reaction equation

HRID 2410592 reaction equation
[NH2:1][C:2](=[N:22][OH:23])[C:3]1[CH:19]=[CH:18][C:6]([CH2:7][N:8]([CH3:17])[CH2:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])=[C:5]([O:20][CH3:21])[CH:4]=1.[CH3:24][O:25][CH2:26][C:27]1[CH:32]=[C:31]([C:33](O)=O)[CH:30]=[CH:29][C:28]=1[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[CH3:42]>>[CH3:21][O:20][C:5]1[CH:4]=[C:3]([C:2]2[N:1]=[C:33]([C:31]3[CH:30]=[CH:29][C:28]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=4[CH3:42])=[C:27]([CH2:26][O:25][CH3:24])[CH:32]=3)[O:23][N:22]=2)[CH:19]=[CH:18][C:6]=1[CH2:7][N:8]([CH3:17])[CH2:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11]

Participants

3

Reactant 2

HCID 594958222-(Methoxymethyl)-2'-methylbiphenyl-4-carboxylic acidHCID 76685382HCID 76685382, compound

Product 1

HCID 66678210HCID 66678210, compound

Procedure

The title compound was prepared following the procedure 7, starting from Intermediate 44 and Intermediate 3. It was isolated as a colorless gum. 1H NMR (CDCl3, 400 MHz) δ 8.43 (1H, s), 8.18 (1H, dd, J=7.9, 1.9 Hz), 7.80 (1H, dd, J=7.7, 1.5 Hz), 7.68 (1H, d, J=1.5 Hz), 7.55 (1H, d, J=7.8 Hz), 7.35-7.24 (4H, m), 7.13 (1H, d, J=7.4 Hz), 4.23 (2H, s), 3.95 (3H, s), 3.81 (2H, s), 3.33 (3H, s), 3.24 (2H, s), 2.44 (3H, s), 2.08 (3H, s), 1.49 (9H, s).

Workup

  1. customIt was isolated as a colorless gum

Sources & evidence

ORD record
ord-c765f3ed3e974bd6aa00f37b1b3d8a61
Source dataset
uspto-grants-2014_08
Patent number
US08815919B2

Reaction notes

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