Hydrochloric Acid → HCID 131731802, compound

Participants

Reaction Conditions

Reaction Steps

To tert-butyl 2-((2-methoxy-4-(5-(2-(methoxymethyl)-2′-methylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl)benzyl)(methyl)amino)acetate (52 mg, 0.09 mmol) was added a 4N solution of HCl in dioxane (3 mL) and the mixture was heated in a tube at 70° C. for 3 hours. The solvent was then removed in vacuo to give the title compound as a white solid (36 mg, 78%). 1H NMR (DMSO-d6, 400 MHz) δ 8.28 (1H, s), 8.16 (1, dd, J=7.9, 1.9 Hz), 7.72 (1H, dd, J=7.8, 1.5 Hz), 7.65-7.58 (2H, m), 7.40 (1H, d, J=7.9 Hz), 7.33 (2H, d, J=4.4 Hz), 7.30-7.25 (1H, m), 7.11 (1H, d, J=7.4 Hz), 4.20-4.11 (2H, m), 3.97 (2H, s), 3.91 (3H, s), 3.25-3.20 (5H, m), 2.48 (3H, s), 2.00 (3H, s). LC/MS (Method B): 488 (M+H)+. HPLC (Method F) Rt 3.15 min (Purity: 97.2%).

Provenance & Evidence