Sarcosine t-butyl ester hydrochloride → HCID 46940742, compound

HRID 2410597Notes

Reaction equation

HRID 2410597 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]2[O:14][N:13]=[C:12]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22]O)=[CH:17][CH:16]=3)[N:11]=2)[CH:7]=[CH:6][C:5]=1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[CH3:30].Cl.[CH3:32][NH:33][CH2:34][C:35]([O:37]C(C)(C)C)=[O:36]>>[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]2[O:14][N:13]=[C:12]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][N:33]([CH2:34][C:35]([OH:37])=[O:36])[CH3:32])=[CH:17][CH:16]=3)[N:11]=2)[CH:7]=[CH:6][C:5]=1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[CH3:30]

Participants

3

Reactant 2

HCID 11252350Sarcosine t-butyl ester hydrochlorideHCID 66678497HCID 66678497, compound

Product 1

HCID 46940742HCID 46940742, compound

Procedure

The title compound was prepared following the procedure described for Example 86 Steps 2 to 4, but starting from 2-(4-(5-(2-(methoxymethyl)-2′-methylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethanol and tert-butyl N-methylglycinate hydrochloride to give the title compound as a white solid. LC/MS (Method B): 470.0 (M−H)−; 472.0 (M+H)+. HPLC (Method F) Rt 3.22 min (Purity: 96.8%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-ba71fe08397f442c991c04edb5c03fdb
Source dataset
uspto-grants-2014_08
Patent number
US08815919B2

Reaction notes

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