2-(Methoxymethyl)-2'-methylbiphenyl-4-carboxylic acid → HCID 66677702, compound

Participants

Reaction Steps

Tert-butyl N-(3-chloro-5-{5-[2-(methoxymethyl)-2′-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)-N-methylglycinate was prepared following the general procedure 3 starting from Intermediate 3 and Intermediate 43. It was hydrolyzed following general procedure 8 to afford the title compound as a white powder. 1H NMR (DMSO-d6, 400 MHz) δ 8.34 (m, 1H), 8.30 (m, 1H), 8.17 (m, 2H), 8.07 (m, 1H), 7.91 (m, 1H), 7.44 (d, J=7.8 Hz, 1H), 4.46 (m, 1H), 4.20 (m, 2H), 4.09 (m, 2H), 3.25 (s, 3H), 2.80 (s, 3H), 2.03 (s, 3H). LC/MS (Method B): 492.0 (M+H)+, 490.1 (M−H)−. HPLC (Method A) Rt 4.31 min (Purity: 99%).

Provenance & Evidence