HCID 66678519, compound → HCID 86661516, compound

Participants

Reaction Conditions

Reaction Steps

(4-(5-(2-(methoxymethyl)-2′-methylbiphenyl-4-yl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)methanol (401 mg, 1.0 mmol) was dissolved in dioxane (10 mL) and manganese dioxide (1.0 g, 11.6 mmol) was added. The mixture was heated at 70° C. overnight and then the solvent was removed in vacuo. The residue was triturated with a mixture of petrol and diethyl ether to give the title compound as a white solid (361 mg, 90%). 1H NMR (CDCl3, 400 MHz) δ 10.10 (1H, s), 8.45 (1H, s), 8.33 (1H, d, J=8.3 Hz), 8.19 (1H, dd, J=7.8, 1.9 Hz), 7.87 (2H, d, J=6.9 Hz), 7.38-7.24 (4H, m), 7.14 (1H, d, J=7.4 Hz), 4.24-4.21 (2H, m), 3.34 (3H, s), 2.81 (3H, s), 2.09 (3H, s).

Provenance & Evidence